Marble Burying Test Anxiety

The epm situation rests on the conflict between the innate tendencies of rodents to explore novel environments and avoid open and brightly lit areas.

Marble burying test anxiety.

Marble burying behavior gauges the level of anxiety in a mouse when it encounters unfamiliar objects. For the communication domain neonatal ultrasonic vocalization and olfactory habituation test toward social and non social odor are described. Marble burying is an animal model used in scientific research to depict anxiety or obsessive compulsive disorder ocd behavior. It has been shown to be sensitive to benzodiazepines as these compounds reduce burying behaviour when.

The mouse is treated with the vehicle or compound 30 minutes before the test. Marbles are placed evenly onto the walls of an empty cage. An increasing number of investigators utilize the marble burying assay despite the paucity of information available regarding what underlies the behavior. In this unit behavioral tests are described that are relevant to the domains affected in asd.

We tested the possibility that a genetic component underlies marble burying in mice and if there is a genetic correlation with other anxiety like traits. In this task the animal is placed in the centre of the maze. This test has some predictive value for anti depressant and or anxiolytic drugs. Mice which are placed individually in a cage bury glass marbles that are present in the cage.

The elevated plus maze epm test is used to evaluate the relative anxiety status of mice or rats. The marble burying test is a useful model of both obsessive compulsive like ocd behavior and or anxiety like behavior. For the repetitive domain the t maze spontaneous alternation test and marble burying test are described. Marble burying the marble burying test is a useful model of neophobia 1 anxiety 1 7 and obsessive compulsive behavior 8 11.

Since findings reported in the literature indicate that marble burying behavior. Marble burying as an anxiety model in conclusion although marble burying was reduced by doses of diazepam and zimeldine which did not affect activity in a locomotor test we have not been able to find other evidence that marble burying models anxiety either from its behavioral characteristics or from the actions of anxiogenic agents. It has also been proposed that the test may have predictive validity for the screening of novel antidepressants 12 15 anxiolytics 15 16 and antipsychotics 17 19. It has also been proposed that the test may have predictive validity for the screening of novel antidepressants 12 15 anxiolytics 15 16 and antipsychotics 17 19.

It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding. When put in a cage with marbles mice with ocd like symptoms tend to engage in a high degree of repetitive behaviors including digging while mice with a high degree of anxiety tend to engage in a high degree of digging in novel contexts potentially as a means to attempt. The animal is then placed in the cage containing the marbles. From here it can walk down any of four runways.